A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase.

Chen, Hsin-Mei

A chemical compound commonly used to inhibit PKR, , protects neurons by inhibiting cyclin-dependent kinase. [electronic resource] - The European journal of neuroscience Nov 2008 - 2003-16 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1460-9568

10.1111/j.1460-9568.2008.06491.x doi


Animals
Animals, Newborn
Apoptosis--drug effects
Benzothiazoles--pharmacology
Cell Cycle--drug effects
Cell Line
Cyclin-Dependent Kinases--antagonists & inhibitors
Enzyme Inhibitors--pharmacology
Eukaryotic Initiation Factor-2--drug effects
Humans
Imidazoles--pharmacology
Nerve Degeneration--drug therapy
Neurodegenerative Diseases--drug therapy
Neurons--drug effects
Rats
Rats, Wistar
eIF-2 Kinase--antagonists & inhibitors