Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors.

Labrie, Viviane

Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors. [electronic resource] - Pharmacology, biochemistry, and behavior Feb 2009 - 610-20 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0091-3057

10.1016/j.pbb.2008.09.016 doi


Animals
Antipsychotic Agents--pharmacology
Anxiety--genetics
Carrier Proteins--genetics
D-Amino-Acid Oxidase--metabolism
Female
Glycine--metabolism
Male
Maze Learning--drug effects
Mice
Mice, Inbred C57BL
Motor Activity--drug effects
Mutation--physiology
Nerve Tissue Proteins--genetics
Receptors, N-Methyl-D-Aspartate--drug effects
Sarcosine--analogs & derivatives
Serine--pharmacology
Social Behavior
Space Perception--drug effects