Synthesis and siderophore and antibacterial activity of N5-acetyl-N5-hydroxy-L-ornithine-derived siderophore-beta-lactam conjugates: iron-transport-mediated drug delivery.

Dolence, E K

Synthesis and siderophore and antibacterial activity of N5-acetyl-N5-hydroxy-L-ornithine-derived siderophore-beta-lactam conjugates: iron-transport-mediated drug delivery. [electronic resource] - Journal of medicinal chemistry Mar 1991 - 968-78 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm00107a014 doi


Anti-Bacterial Agents--chemical synthesis
Azetidines--chemical synthesis
Biological Transport
Cephalosporins--chemistry
Chemical Phenomena
Chemistry
Drug Carriers
Escherichia coli--drug effects
Ferrichrome--analogs & derivatives
Iron--metabolism
Iron Chelating Agents--chemical synthesis
Lactams
Molecular Structure
Mutation
Shigella flexneri--drug effects
Siderophores
beta-Lactams