A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies.

Iasonos, Alexia

A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies. [electronic resource] - Clinical trials (London, England) 2008 - 465-77 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1740-7745

10.1177/1740774508096474 doi


Algorithms
Biomarkers--analysis
Clinical Trials, Phase I as Topic--methods
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Humans