Synthesis of novel beta-lactone inhibitors of fatty acid synthase.

Richardson, Robyn D

Synthesis of novel beta-lactone inhibitors of fatty acid synthase. [electronic resource] - Journal of medicinal chemistry Sep 2008 - 5285-96 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm800321h doi


Antineoplastic Agents--chemical synthesis
Cell Death--drug effects
Cell Line, Tumor
Fatty Acid Synthases--antagonists & inhibitors
Fibroblasts
Humans
Lactones--chemical synthesis
Neoplasms--drug therapy
Orlistat
Solubility
Structure-Activity Relationship