Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.

Nishikii, Hidekazu

Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. [electronic resource] - The Journal of experimental medicine Aug 2008 - 1917-27 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1540-9538

10.1084/jem.20071482 doi


Animals
Blood Platelets--cytology
Cells, Cultured
Dipeptides--pharmacology
Embryonic Stem Cells--cytology
In Vitro Techniques
Integrin beta3--metabolism
Megakaryocytes--cytology
Metalloproteases--antagonists & inhibitors
Mice
Platelet Glycoprotein GPIb-IX Complex--metabolism
Platelet Membrane Glycoprotein IIb--metabolism
Protease Inhibitors--pharmacology
Proto-Oncogene Proteins c-kit--metabolism
Thrombopoiesis--drug effects
Thrombosis--etiology