SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1.

Bertram, Lisa S

SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1. [electronic resource] - Journal of medicinal chemistry Jul 2008 - 4340-5 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm8003202 doi


Animals
Enzyme Activation
Female
Glucokinase--metabolism
Hypoglycemic Agents--adverse effects
Male
Mice
Mice, Inbred C57BL
Microsomes, Liver--enzymology
Rats
Rats, Sprague-Dawley
Spectrometry, Mass, Electrospray Ionization
Structure-Activity Relationship
Sulfones--adverse effects
Thiazoles--adverse effects