Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line.

Zrieki, Afraa

Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line. [electronic resource] - Pharmaceutical research Sep 2008 - 1991-2001 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0724-8741

10.1007/s11095-008-9596-1 doi


ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters--genetics
Antineoplastic Agents--pharmacology
Caco-2 Cells
Celecoxib
Colorectal Neoplasms--drug therapy
Cyclooxygenase 1--metabolism
Cyclooxygenase 2--metabolism
Cyclooxygenase 2 Inhibitors--pharmacology
Dinoprostone--metabolism
Down-Regulation
Drug Resistance, Neoplasm--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Humans
Indomethacin--analogs & derivatives
Naproxen--pharmacology
Neoplasm Proteins--genetics
Pyrazoles--pharmacology
RNA, Messenger--metabolism
Reproducibility of Results
Sulfonamides--pharmacology
Time Factors