Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.

Kessenbrock, Kai

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. [electronic resource] - The Journal of clinical investigation Jul 2008 - 2438-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9738

10.1172/JCI34694 doi


Animals
Antigen-Antibody Complex--pharmacology
Arthus Reaction--metabolism
Cell Movement--drug effects
Chemotaxis, Leukocyte--drug effects
Granulins
Inflammation--drug therapy
Intercellular Signaling Peptides and Proteins--metabolism
Leukocyte Elastase--genetics
Mice
Mice, Inbred Strains
Mice, Knockout
Models, Biological
Myeloblastin--genetics
Neutrophil Activation--drug effects
Neutrophils--cytology
Ovalbumin--immunology
Progranulins
Respiratory Burst--drug effects
Tetradecanoylphorbol Acetate--pharmacology