Oncocalyxone A inhibits human platelet aggregation by increasing cGMP and by binding to GP Ibalpha glycoprotein.

Ferreira, M A D

Oncocalyxone A inhibits human platelet aggregation by increasing cGMP and by binding to GP Ibalpha glycoprotein. [electronic resource] - British journal of pharmacology Jul 2008 - 1216-24 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0007-1188

10.1038/bjp.2008.199 doi


Adenosine Diphosphate--pharmacology
Adenosine Triphosphate--metabolism
Adolescent
Adult
Anthraquinones--isolation & purification
Blood Platelets--drug effects
Cyclic AMP--biosynthesis
Cyclic GMP--blood
Cyclic Nucleotide Phosphodiesterases, Type 5--blood
Female
Flow Cytometry
Guanylate Cyclase--blood
Humans
In Vitro Techniques
Male
Middle Aged
Nitric Oxide--metabolism
Platelet Aggregation--drug effects
Platelet Aggregation Inhibitors--metabolism
Platelet Glycoprotein GPIb-IX Complex--metabolism
Protein Binding
Thromboxane A2--physiology