alpha2A-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice.

Fagerholm, V

alpha2A-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice. [electronic resource] - British journal of pharmacology Jul 2008 - 1287-96 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0007-1188

10.1038/bjp.2008.186 doi


Adrenergic alpha-2 Receptor Antagonists
Adrenergic alpha-Antagonists--pharmacology
Adrenergic beta-Antagonists--pharmacology
Animals
Atropine Derivatives--pharmacology
Benzofurans--pharmacology
Blood Glucose--metabolism
Drug Synergism
Fasting--physiology
Glyburide--pharmacology
Hypoglycemic Agents--pharmacology
Imidazoles--pharmacology
Insulin--blood
Insulin Secretion
Isoquinolines--pharmacology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscarinic Antagonists--pharmacology
Naphthyridines--pharmacology
Phentolamine--pharmacology
Propranolol--pharmacology
Receptors, Adrenergic, alpha-2--genetics