Loss of DNA damage checkpoint genes: switch from preferential induction of point mutations to chromosomal damage precedes the transition towards an aggressive cancer type.

Hengstler, J G

Loss of DNA damage checkpoint genes: switch from preferential induction of point mutations to chromosomal damage precedes the transition towards an aggressive cancer type. [electronic resource] - Archives of toxicology Jun 2008 - 341-2 p. digital

Publication Type: Comment; Editorial

0340-5761

10.1007/s00204-008-0295-9 doi


Aneuploidy
Cell Cycle--genetics
Cell Transformation, Neoplastic--genetics
Chromosomal Instability
DNA Damage--genetics
Gene Expression Regulation, Neoplastic
Genes, cdc--physiology
Humans
Mutagenesis
Point Mutation--genetics
Urinary Bladder Neoplasms--genetics