DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.

Vermulst, Marc

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. [electronic resource] - Nature genetics Apr 2008 - 392-4 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1546-1718

10.1038/ng.95 doi


Aging, Premature--genetics
Animals
Base Sequence
Catalase--genetics
DNA Polymerase gamma
DNA Repair
DNA, Mitochondrial--genetics
DNA-Directed DNA Polymerase--genetics
Electron Transport Complex IV--genetics
Mice
Mice, Knockout
Mice, Transgenic
Molecular Sequence Data
Mutagenesis
Oxidative Stress
Phenotype
Point Mutation--genetics
Sequence Deletion
Sequence Homology, Nucleic Acid
Tissue Distribution