2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.

Chen, Yuhpyng L

2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. [electronic resource] - Journal of medicinal chemistry Mar 2008 - 1385-92 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm070579c doi


Action Potentials--drug effects
Administration, Oral
Adrenocorticotropic Hormone--blood
Aminopyridines--chemical synthesis
Animals
Antidepressive Agents--chemical synthesis
Cerebral Cortex--metabolism
Corticotropin-Releasing Hormone--pharmacology
Dogs
Fasting
Humans
Injections, Intravenous
Locus Coeruleus--physiology
Male
Pituitary Gland--metabolism
Postprandial Period
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Corticotropin-Releasing Hormone--antagonists & inhibitors
Reflex, Startle--drug effects
Structure-Activity Relationship
CRF Receptor, Type 1