Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.

Vinogradova, Tatiana M

Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases. [electronic resource] - Circulation research Apr 2008 - 761-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

1524-4571

10.1161/CIRCRESAHA.107.161679 doi


1-Methyl-3-isobutylxanthine--pharmacology
Animals
Biological Clocks--physiology
Calcium--metabolism
Calcium-Binding Proteins--metabolism
Cyclic AMP--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
Enzyme Activation
Heart Rate--physiology
Patch-Clamp Techniques
Phosphodiesterase Inhibitors--pharmacology
Phosphoric Diester Hydrolases--drug effects
Phosphorylation
Rabbits
Ryanodine Receptor Calcium Release Channel--metabolism
Signal Transduction--physiology
Sinoatrial Node--metabolism