In vitro metabolism of KBH-A40, a novel delta-lactam-based histone deacetylase (HDAC) inhibitor, in human liver microsomes and serum.

Kim, H M

In vitro metabolism of KBH-A40, a novel delta-lactam-based histone deacetylase (HDAC) inhibitor, in human liver microsomes and serum. [electronic resource] - Xenobiotica; the fate of foreign compounds in biological systems Mar 2008 - 281-93 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0049-8254

10.1080/00498250701813222 doi


Animals
Biotransformation--drug effects
Chromatography, Liquid
Drug Stability
Enzyme Inhibitors--blood
Histone Deacetylase Inhibitors
Humans
Hydroxamic Acids--blood
Lactams--blood
Male
Mass Spectrometry
Microsomes, Liver--drug effects
Pyridones--blood
Rats
Rats, Sprague-Dawley
Time Factors