Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.

Simonsen, Shane M

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. [electronic resource] - The Journal of biological chemistry Apr 2008 - 9805-13 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M709303200 doi


Animals
Cyclotides--chemistry
Cystine Knot Motifs--physiology
Drosophila melanogaster
Epitopes--chemistry
Insecticides--chemistry
Mutagenesis, Site-Directed
Peptide Mapping
Plant Proteins--chemistry
Structure-Activity Relationship