Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.

Ott, Gregory R

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. [electronic resource] - Bioorganic & medicinal chemistry letters Mar 2008 - 1577-82 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2008.01.075 doi


ADAM Proteins--antagonists & inhibitors
ADAM17 Protein
Animals
Area Under Curve
Benzamides--blood
Biological Availability
Dogs
Half-Life
Molecular Structure
Rats
Structure-Activity Relationship