Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release.

Kuehn, Hye Sun

Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release. [electronic resource] - Cellular signalling Apr 2008 - 625-36 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

0898-6568

10.1016/j.cellsig.2007.11.016 doi


Animals
Antigens--metabolism
Calcium Signaling
Cell Degranulation--drug effects
Cell Membrane--enzymology
Cells, Cultured
Cytokines--metabolism
Dinoprostone--metabolism
Enzyme Activation
Hypersensitivity--enzymology
Inositol 1,4,5-Trisphosphate--metabolism
Macrophages--drug effects
Mice
Mice, Inbred C57BL
Pertussis Toxin--pharmacology
Phosphatidylinositol 3-Kinases--metabolism
Phospholipase C beta--metabolism
Phospholipase C gamma--metabolism
Phosphorylation
Protein Kinase C--metabolism
Protein Kinase C beta
Protein Kinase C-alpha--metabolism
Protein Transport
Receptor Aggregation
Receptor Cross-Talk
Receptors, IgE--metabolism
Receptors, Prostaglandin E--metabolism
Signal Transduction--drug effects
Time Factors