Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole.
Srivastava, Brijesh Kumar
Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole. [electronic resource] - Bioorganic & medicinal chemistry letters Feb 2008 - 963-8 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2007.12.036 doi
Animals
Combinatorial Chemistry Techniques
Cricetinae
Cricetulus
Drug Design
Humans
Imidazoles--chemical synthesis
Models, Molecular
Molecular Structure
Oxazoles--chemical synthesis
Pyrazoles--chemical synthesis
Receptor, Cannabinoid, CB1--antagonists & inhibitors
Structure-Activity Relationship
Sulfonamides--chemical synthesis
Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole. [electronic resource] - Bioorganic & medicinal chemistry letters Feb 2008 - 963-8 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2007.12.036 doi
Animals
Combinatorial Chemistry Techniques
Cricetinae
Cricetulus
Drug Design
Humans
Imidazoles--chemical synthesis
Models, Molecular
Molecular Structure
Oxazoles--chemical synthesis
Pyrazoles--chemical synthesis
Receptor, Cannabinoid, CB1--antagonists & inhibitors
Structure-Activity Relationship
Sulfonamides--chemical synthesis