Pharmacokinetics and bioavailability of the novel rivastigmine transdermal patch versus rivastigmine oral solution in healthy elderly subjects.

Lefèvre, Gilbert

Pharmacokinetics and bioavailability of the novel rivastigmine transdermal patch versus rivastigmine oral solution in healthy elderly subjects. [electronic resource] - Journal of clinical pharmacology Feb 2008 - 246-52 p. digital

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

0091-2700

10.1177/0091270007312154 doi


Administration, Cutaneous
Administration, Oral
Aged--physiology
Area Under Curve
Benzylamines--blood
Biological Availability
Cholinesterase Inhibitors--administration & dosage
Chromatography, High Pressure Liquid
Cross-Over Studies
Dizziness--chemically induced
Female
Half-Life
Headache--chemically induced
Humans
Male
Metabolic Clearance Rate
Middle Aged
Nausea--chemically induced
Phenethylamines
Phenols--blood
Phenylcarbamates--blood
Rivastigmine
Sleep Initiation and Maintenance Disorders--chemically induced
Solutions
Tandem Mass Spectrometry
Vomiting--chemically induced