HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.

Johnston, Paul A

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. [electronic resource] - Assay and drug development technologies Dec 2007 - 737-50 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1540-658X

10.1089/adt.2007.101 doi


Antiviral Agents--chemical synthesis
Chromatography, Liquid
Data Interpretation, Statistical
Drug Evaluation, Preclinical
Drug Stability
Indicators and Reagents
Ligands
Mass Spectrometry
Models, Molecular
Protease Inhibitors--chemical synthesis
Structure-Activity Relationship
Viral Nonstructural Proteins--antagonists & inhibitors
West Nile Fever--virology
West Nile virus--drug effects