Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.

Roztocil, Eliza

Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation. [electronic resource] - Journal of vascular surgery Dec 2007 - 1253-1259 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0741-5214

10.1016/j.jvs.2007.08.013 doi


Animals
Cell Movement--drug effects
Cells, Cultured
Enzyme Activation
Estrenes--pharmacology
GTP-Binding Protein alpha Subunits, G12-G13--antagonists & inhibitors
Lysophospholipids--metabolism
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Muscle, Smooth, Vascular--drug effects
Myocytes, Smooth Muscle--drug effects
NADPH Oxidases--antagonists & inhibitors
Onium Compounds--pharmacology
Pertussis Toxin--pharmacology
Phosphodiesterase Inhibitors--pharmacology
Phospholipase C beta--antagonists & inhibitors
Phospholipase C gamma--metabolism
Phosphorylation
Pyrrolidinones--pharmacology
RNA Interference
RNA, Small Interfering--metabolism
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species--metabolism
Signal Transduction--drug effects
Sphingosine--analogs & derivatives
Time Factors
p38 Mitogen-Activated Protein Kinases--metabolism