Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.

Wang, Yongyu

Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. [electronic resource] - The Journal of biological chemistry Jan 2008 - 1799-807 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0021-9258

10.1074/jbc.M705747200 doi


Adrenergic alpha-Agonists
Adrenergic beta-2 Receptor Agonists
Animals
Cells, Cultured
Enzyme Inhibitors--pharmacology
Epinephrine--metabolism
G-Protein-Coupled Receptor Kinase 2--metabolism
GTP-Binding Protein alpha Subunits, Gi-Go--metabolism
Mice
Mice, Knockout
Myocardial Contraction--drug effects
Myocytes, Cardiac--cytology
Norepinephrine--metabolism
Okadaic Acid--pharmacology
Phosphorylation--drug effects
Receptors, Adrenergic, beta-2--metabolism
Signal Transduction--drug effects
Time Factors