Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A.

Plaumann, Silke

Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A. [electronic resource] - Molecular pharmacology Mar 2008 - 652-9 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1521-0111

10.1124/mol.107.040782 doi


Animals
Apoptosis--drug effects
Calcineurin Inhibitors
Caspase 3--metabolism
Cell Death--drug effects
Cell Line
Cell Survival--drug effects
Cyclosporine--pharmacology
DNA Fragmentation
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Formazans--metabolism
Immunohistochemistry
Immunosuppressive Agents--pharmacology
Inhibitory Concentration 50
Insulin-Secreting Cells--drug effects
Kinetics
MAP Kinase Kinase Kinases--analysis
Mice
Statistics as Topic
Tacrolimus--pharmacology
Tetrazolium Salts--metabolism
bcl-X Protein--genetics