Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites.

Herlands, Robin A

Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites. [electronic resource] - European journal of immunology Dec 2007 - 3339-51 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0014-2980

10.1002/eji.200737752 doi


Animals
Antibodies, Antinuclear--immunology
Autoimmunity--genetics
B-Lymphocyte Subsets--immunology
Chromatin--immunology
Disease Models, Animal
Genetic Predisposition to Disease
Immunoglobulin G--immunology
Lupus Erythematosus, Systemic--genetics
Lymphocyte Activation--immunology
Lymphocyte Cooperation
Mice
Mice, Inbred BALB C
Mice, Inbred MRL lpr--immunology
Mice, Transgenic
Nucleosomes--immunology
Organ Specificity
Particle Size
Rheumatoid Factor--immunology
Somatic Hypermutation, Immunoglobulin--immunology
Specific Pathogen-Free Organisms
Spleen--immunology
Toll-Like Receptors--immunology