VEGF and thrombin induce MKP-1 through distinct signaling pathways: role for MKP-1 in endothelial cell migration.

Kinney, Corttrell M

VEGF and thrombin induce MKP-1 through distinct signaling pathways: role for MKP-1 in endothelial cell migration. [electronic resource] - American journal of physiology. Cell physiology Jan 2008 - C241-50 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0363-6143

10.1152/ajpcell.00187.2007 doi


Animals
Cell Movement--drug effects
Cells, Cultured
Dual Specificity Phosphatase 1--deficiency
Endothelial Cells--drug effects
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases--genetics
Humans
JNK Mitogen-Activated Protein Kinases--genetics
Mice
Mice, Transgenic
Neovascularization, Physiologic--drug effects
Neuropilins--metabolism
Peptide Fragments--pharmacology
Phosphorylation
Proto-Oncogene Proteins c-fyn--metabolism
RNA Interference
RNA, Small Interfering--metabolism
Recombinant Proteins--metabolism
Signal Transduction--drug effects
Thrombin--metabolism
Time Factors
Transfection
Up-Regulation
Vascular Endothelial Growth Factor A--metabolism
Vascular Endothelial Growth Factor Receptor-2--metabolism
p38 Mitogen-Activated Protein Kinases--genetics
src-Family Kinases--metabolism