The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins.

DeRosa, Adam M

The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins. [electronic resource] - Journal of cell science Dec 2007 - 4107-16 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

0021-9533

10.1242/jcs.012237 doi


Animals
Cataract--genetics
Connexins--genetics
Electrophysiology
Eye Proteins--genetics
Female
Gap Junctions--genetics
Genetic Engineering--methods
HeLa Cells
Heterozygote
Humans
Immunohistochemistry
Ion Channel Gating--physiology
Lens, Crystalline--metabolism
Mice
Mice, Knockout
Microinjections
Models, Biological
Mutation
Oocytes--physiology
Patch-Clamp Techniques
Transfection
Xenopus