Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.

Hay, Michael P

Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport. [electronic resource] - Journal of medicinal chemistry Dec 2007 - 6392-404 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm070670g doi


Algorithms
Animals
Biological Transport
Cell Hypoxia
Cell Line, Tumor
Humans
Mice
Mice, Nude
Models, Biological
Neoplasm Transplantation
Neoplasms--blood supply
Transplantation, Heterologous
Triazines--chemistry