Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors.

Baur, Roland

Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors. [electronic resource] - Journal of neurochemistry Dec 2007 - 2556-64 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1471-4159

10.1111/j.1471-4159.2007.04982.x doi


Amino Acid Substitution--physiology
Animals
Cysteine--physiology
Dose-Response Relationship, Drug
Electrophysiological Phenomena
Excitatory Amino Acid Agonists--pharmacology
GABA Agonists--pharmacology
Histidine--physiology
Humans
Hydrogen-Ion Concentration
Oocytes--metabolism
Patch-Clamp Techniques
Pyridines--pharmacology
Receptors, GABA-A--drug effects
Structure-Activity Relationship
Xenopus
Zolpidem
gamma-Aminobutyric Acid--pharmacology