Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

Iben, Lawrence G

Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. [electronic resource] - The Journal of biological chemistry Dec 2007 - 36829-36 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.M707002200 doi


Alzheimer Disease--enzymology
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Peptides--antagonists & inhibitors
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Aspartic Acid Endopeptidases--antagonists & inhibitors
Binding Sites
Catalytic Domain
Cell Line
Humans
Ligands
Models, Molecular
Presenilins--antagonists & inhibitors
Protease Inhibitors--pharmacology
Sulindac--analogs & derivatives