The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis.

Venneti, Sriram

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis. [electronic resource] - Neurobiology of disease Feb 2008 - 232-41 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0969-9961

10.1016/j.nbd.2007.08.016 doi


Acetamides--pharmacokinetics
Adult
Aged
Analysis of Variance
Animals
Antigens, CD--metabolism
Antigens, Differentiation, Myelomonocytic--metabolism
Astrocytes--drug effects
Brain--diagnostic imaging
Bucladesine--pharmacology
Dose-Response Relationship, Drug
Encephalitis, Viral--pathology
Female
Humans
Lentivirus
Lipopolysaccharides--pharmacology
Macaca mulatta
Macrophages--drug effects
Male
Middle Aged
Nerve Tissue Proteins--metabolism
Phenyl Ethers--pharmacokinetics
Positron-Emission Tomography
Protein Binding--drug effects
Synapses--drug effects