Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.

Hicks, Kevin O

Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine. [electronic resource] - International journal of radiation oncology, biology, physics Oct 2007 - 560-71 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0360-3016

10.1016/j.ijrobp.2007.05.049 doi


Animals
Antineoplastic Agents--pharmacokinetics
Biological Transport
Cell Hypoxia--physiology
Drug Evaluation, Preclinical
Humans
Mice
Mice, Nude
Models, Biological
Nitrogen Mustard Compounds--pharmacokinetics
Oxygen--physiology
Partial Pressure
Prodrugs--pharmacokinetics
Radiation-Sensitizing Agents--pharmacokinetics
Tirapazamine
Triazines--pharmacokinetics
Tumor Cells, Cultured