1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists.

Micheli, Fabrizio

1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists. [electronic resource] - Journal of medicinal chemistry Oct 2007 - 5076-89 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0705612 doi


Acetylcholine--metabolism
Administration, Oral
Alcohol Drinking--prevention & control
Animals
Benzazepines--chemical synthesis
Brain--blood supply
Cocaine--pharmacology
Conditioning, Operant--drug effects
ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels--metabolism
Guinea Pigs
Histamine H1 Antagonists--chemical synthesis
Humans
In Vitro Techniques
Male
Mice
Mice, Inbred C57BL
Microsomes, Liver--drug effects
Models, Molecular
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D3--agonists
Receptors, Histamine H1--metabolism
Structure-Activity Relationship
Tobacco Use Disorder--prevention & control
Triazoles--chemical synthesis