Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches.

Tinwell, Helen

Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches. [electronic resource] - Toxicological sciences : an official journal of the Society of Toxicology Nov 2007 - 54-65 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Study

1096-6080

10.1093/toxsci/kfm208 doi


Adrenal Glands--drug effects
Androgen Antagonists--toxicity
Animals
Biomarkers, Pharmacological--metabolism
Body Weight--drug effects
Dichlorodiphenyl Dichloroethylene--toxicity
Dose-Response Relationship, Drug
Endocrine Disruptors--toxicity
Epididymis--drug effects
Flutamide--toxicity
Genitalia, Male--drug effects
Kidney--drug effects
L-Amino Acid Oxidase--metabolism
Linuron--toxicity
Liver--drug effects
Male
Organ Size--drug effects
Prostate--drug effects
Proteomics
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Seminal Vesicles--drug effects
Testis--drug effects
Testosterone Propionate--pharmacology
Time Factors
Toxicity Tests--methods
Weaning