Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum.
Bychkov, Evgeny
Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum. [electronic resource] - Journal of neurochemistry Aug 2007 - 699-711 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0022-3042
10.1111/j.1471-4159.2007.04586.x doi
Animals
Corpus Striatum--drug effects
Dopamine--deficiency
Dopamine Agents--pharmacology
Dopamine Agonists--pharmacology
Enzyme Activation--drug effects
Glycogen Synthase Kinase 3--drug effects
Glycogen Synthase Kinase 3 beta
Levodopa--pharmacology
Mitogen-Activated Protein Kinase 1--drug effects
Opioid Peptides--drug effects
Oxidopamine
Parkinson Disease--drug therapy
Pergolide--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D3--drug effects
Signal Transduction--drug effects
Up-Regulation--drug effects
Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum. [electronic resource] - Journal of neurochemistry Aug 2007 - 699-711 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0022-3042
10.1111/j.1471-4159.2007.04586.x doi
Animals
Corpus Striatum--drug effects
Dopamine--deficiency
Dopamine Agents--pharmacology
Dopamine Agonists--pharmacology
Enzyme Activation--drug effects
Glycogen Synthase Kinase 3--drug effects
Glycogen Synthase Kinase 3 beta
Levodopa--pharmacology
Mitogen-Activated Protein Kinase 1--drug effects
Opioid Peptides--drug effects
Oxidopamine
Parkinson Disease--drug therapy
Pergolide--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D3--drug effects
Signal Transduction--drug effects
Up-Regulation--drug effects