Synthesis, cleavage profile, and antitumor efficacy of an albumin-binding prodrug of methotrexate that is cleaved by plasmin and cathepsin B.

Warnecke, André

Synthesis, cleavage profile, and antitumor efficacy of an albumin-binding prodrug of methotrexate that is cleaved by plasmin and cathepsin B. [electronic resource] - Archiv der Pharmazie Aug 2007 - 389-95 p. digital

Publication Type: Journal Article

0365-6233

10.1002/ardp.200700025 doi


Animals
Antineoplastic Agents--chemical synthesis
Cathepsin B--pharmacology
Female
Fibrinolysin--pharmacology
Humans
Methotrexate--metabolism
Mice
Mice, Inbred DBA
Prodrugs--chemical synthesis
Protein Binding
Serum Albumin--metabolism