PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes.

Kerfant, Benoit-Gilles

PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. [electronic resource] - Circulation research Aug 2007 - 400-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4571

10.1161/CIRCRESAHA.107.156422 doi


3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Animals
Calcium--metabolism
Calcium Channels, L-Type--metabolism
Cell Compartmentation--physiology
Class Ib Phosphatidylinositol 3-Kinase
Cyclic AMP--metabolism
Cyclic Nucleotide Phosphodiesterases, Type 3
Cyclic Nucleotide Phosphodiesterases, Type 4
Enzyme Inhibitors--pharmacology
Heart Diseases--metabolism
Isoenzymes--genetics
Mice
Mice, Mutant Strains
Myocardial Contraction--physiology
Myocytes, Cardiac--cytology
Phosphatidylinositol 3-Kinases--genetics
Ryanodine Receptor Calcium Release Channel--metabolism
Sarcoplasmic Reticulum Calcium-Transporting ATPases--metabolism