Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets.

Konstantinopoulos, Panagiotis A

Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. [electronic resource] - Nature reviews. Drug discovery Jul 2007 - 541-55 p. digital

Publication Type: Journal Article; Review

1474-1776

10.1038/nrd2221 doi


Animals
Antineoplastic Agents--pharmacology
Clinical Trials as Topic
Farnesyltranstransferase--antagonists & inhibitors
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--therapeutic use
Neoplasms--drug therapy
Protein Prenylation--drug effects
Protein Processing, Post-Translational
ras Proteins--metabolism