Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation.

Tang, Qingbo

Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. [electronic resource] - The European journal of neuroscience May 2007 - 2964-72 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0953-816X

10.1111/j.1460-9568.2007.05576.x doi


Amidines--pharmacology
Animals
Benzylamines--pharmacology
Carrageenan--pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Hyperalgesia--drug therapy
Inflammation--drug therapy
Inflammation Mediators--pharmacology
MAP Kinase Signaling System--drug effects
Male
Neurons, Afferent--drug effects
Nitric Oxide--biosynthesis
Nitric Oxide Synthase Type II--antagonists & inhibitors
Nociceptors--drug effects
Pain Measurement
Rats
Rats, Sprague-Dawley
Spinal Cord--drug effects
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors