Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.

Eklund, Birgitta I

Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs. [electronic resource] - Biochimica et biophysica acta Aug 2007 - 1098-103 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-3002

10.1016/j.bbagen.2007.04.001 doi


Amino Acid Substitution
Antimetabolites, Antineoplastic--metabolism
Binding Sites
Catalysis
Glutathione Transferase--genetics
Humans
Kinetics
Mercaptopurine--metabolism
Molecular Structure
Prodrugs--chemistry
Serine--chemistry
Spectrophotometry, Ultraviolet
Substrate Specificity