In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species.

Venkatesh, Pilla Reddy

In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species. [electronic resource] - Biological & pharmaceutical bulletin May 2007 - 1021-4 p. digital

Publication Type: Journal Article

0918-6158

10.1248/bpb.30.1021 doi


Administration, Oral
Animals
Benzimidazoles--blood
Biological Availability
Caco-2 Cells
Cell Membrane Permeability--drug effects
Cytochrome P-450 Enzyme System--metabolism
Dogs
Drug Evaluation, Preclinical
Enzyme Inhibitors--blood
Female
Half-Life
Histone Deacetylase Inhibitors
Humans
Hydroxamic Acids--blood
Male
Metabolic Detoxication, Phase I
Mice
Mice, Inbred BALB C
Microsomes, Liver--drug effects
Pyrroles--blood
Pyrrolidines
Rats
Rats, Wistar
Vorinostat