A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors.

Chen, Jinhua

A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors. [electronic resource] - ACS chemical biology May 2007 - 329-36 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1554-8937

10.1021/cb700025j doi


Cell Line
Drug Design
Humans
Isoenzymes
Ligands
Lipopolysaccharides--pharmacology
Mitogen-Activated Protein Kinase 14--antagonists & inhibitors
Models, Chemical
Piperidines--chemical synthesis
Protein Binding
Protein Kinase Inhibitors--chemical synthesis
Structure-Activity Relationship
Tumor Necrosis Factor-alpha--antagonists & inhibitors