Mutation of the circadian clock gene Per2 alters vascular endothelial function.

Viswambharan, Hema

Mutation of the circadian clock gene Per2 alters vascular endothelial function. [electronic resource] - Circulation Apr 2007 - 2188-95 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4539

10.1161/CIRCULATIONAHA.106.653303 doi


Acetylcholine--pharmacology
Adenosine Triphosphate--pharmacology
Animals
Antioxidants--pharmacology
Aorta, Thoracic--drug effects
Blood Glucose--analysis
Blood Pressure
Cardiovascular Diseases--etiology
Cell Cycle Proteins--genetics
Circadian Rhythm--genetics
Cyclooxygenase 1--biosynthesis
Cyclooxygenase Inhibitors--pharmacology
Endothelium, Vascular--physiopathology
Gene Expression Regulation
Indomethacin--pharmacology
Ionomycin--toxicity
Lipids--blood
Male
Mice
Mice, Knockout
NG-Nitroarginine Methyl Ester--pharmacology
Nitric Oxide--deficiency
Nitric Oxide Donors--pharmacology
Nitric Oxide Synthase Type II--biosynthesis
Nitric Oxide Synthase Type III
Nitroprusside--pharmacology
Nuclear Proteins--genetics
Period Circadian Proteins
Receptor, Muscarinic M3--biosynthesis
Transcription Factors--genetics
Vasodilation--drug effects