Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction.

Bhattacharyya, Sankar

Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. [electronic resource] - The Journal of biological chemistry Jun 2007 - 15954-64 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M608189200 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
CD4-Positive T-Lymphocytes--immunology
CD8-Positive T-Lymphocytes--immunology
Curcumin--pharmacology
Dinoprostone--metabolism
Down-Regulation--drug effects
Enzyme Activation--drug effects
Humans
Interleukin Receptor Common gamma Subunit--biosynthesis
Janus Kinase 3--genetics
Lymphocyte Depletion
Mice
Neoplasms--drug therapy
Proto-Oncogene Proteins c-bcl-2--genetics
Recovery of Function--drug effects
STAT5 Transcription Factor--genetics
Signal Transduction--drug effects
bcl-2-Associated X Protein--genetics