An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure.

Shimoishi, Kazuki

An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. [electronic resource] - Pharmaceutical research Jul 2007 - 1283-9 p. digital

Publication Type: Journal Article

0724-8741

10.1007/s11095-007-9248-x doi


Administration, Oral
Animals
Antioxidants--administration & dosage
Biomarkers--blood
Carbon--administration & dosage
Cells, Cultured
Disease Models, Animal
Dose-Response Relationship, Drug
Endothelial Cells--drug effects
Gene Expression--drug effects
Humans
Indican--blood
Kidney Failure, Chronic--drug therapy
Male
Nephrectomy
Organic Anion Transport Protein 1--genetics
Oxidation-Reduction
Oxidative Stress--drug effects
Oxides--administration & dosage
RNA, Messenger--metabolism
Rats
Rats, Wistar
Reactive Oxygen Species--metabolism
Serum Albumin--metabolism
Time Factors
Transforming Growth Factor beta1--genetics