The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation.

Lee, Sung A

The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation. [electronic resource] - The Journal of biological chemistry May 2007 - 15271-83 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

0021-9258

10.1074/jbc.M701362200 doi


Anthracenes--pharmacology
Antibiotics, Antineoplastic--pharmacology
Apoptosis--drug effects
Breast Neoplasms--drug therapy
Caspases--metabolism
Cell Line, Tumor
Doxorubicin--pharmacology
Drug Resistance, Multiple--drug effects
Drug Resistance, Neoplasm--drug effects
Drug Screening Assays, Antitumor
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Female
Gene Expression Regulation, Enzymologic--drug effects
Gene Expression Regulation, Leukemic--drug effects
Humans
JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors
Lamin Type A--metabolism
MAP Kinase Kinase 4--antagonists & inhibitors
Neoplasm Proteins--metabolism
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases--metabolism
Protein Kinase C-delta--metabolism
Protein Processing, Post-Translational--drug effects
Pyrimidine Nucleosides--pharmacology