Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.

Rao, Navin L

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jun 2007 - 1154-60 p. digital

Publication Type: Comparative Study; Journal Article

0022-3565

10.1124/jpet.106.115436 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--metabolism
Arachidonic Acid--pharmacology
Ascitic Fluid--drug effects
Benzothiazoles--metabolism
Dogs
Ear--pathology
Edema--pathology
Eicosanoids--metabolism
Enzyme Inhibitors--metabolism
Epoxide Hydrolases--antagonists & inhibitors
Female
Humans
Hydroxyurea--analogs & derivatives
Inflammation--metabolism
Leukotriene B4--metabolism
Leukotriene C4--metabolism
Lipoxins--metabolism
Lipoxygenase Inhibitors
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Neutrophil Infiltration--drug effects
Peritonitis--metabolism
Piperidines--metabolism
Recombinant Proteins--chemistry