Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells.

Ma, Wei

Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells. [electronic resource] - The Journal of biological chemistry May 2007 - 13351-62 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication

0021-9258

10.1074/jbc.M611522200 doi


Animals
Calcineurin--metabolism
Calcineurin Inhibitors
Calcium Signaling--drug effects
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases--metabolism
Calmodulin--metabolism
Cell Line
Cyclosporine--pharmacology
Gene Expression Regulation--drug effects
Humans
Immunosuppressive Agents--pharmacology
Interleukin-12 Subunit p40--biosynthesis
Lipopolysaccharides--pharmacology
MAP Kinase Kinase 4--metabolism
Mice
Monocytes--cytology
NF-kappa B--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Tacrolimus--pharmacology
Transcription, Genetic--drug effects