The immunosuppressant FK506 promotes development of the chondrogenic phenotype in human synovial stromal cells via modulation of the Smad signaling pathway.

Tateishi, K

The immunosuppressant FK506 promotes development of the chondrogenic phenotype in human synovial stromal cells via modulation of the Smad signaling pathway. [electronic resource] - Osteoarthritis and cartilage Jun 2007 - 709-18 p. digital

Publication Type: Journal Article

1063-4584

10.1016/j.joca.2007.01.006 doi


Adult
Cartilage, Articular--drug effects
Chondrocytes--drug effects
Chondrogenesis--drug effects
Female
Gene Expression Regulation--drug effects
Humans
Immunosuppressive Agents--therapeutic use
Male
Middle Aged
Phenotype
Signal Transduction--drug effects
Smad Proteins--drug effects
Stromal Cells--drug effects
Tacrolimus--therapeutic use
Transforming Growth Factor beta1--drug effects